Targeting Antibiotic Resistance: From Diagnostics to Novel Antibiotics
نویسندگان
چکیده
منابع مشابه
Antibiotics and Antibiotic Resistance
A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of acti...
متن کاملTargeting Antibiotic Resistance
Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in...
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Antibiotics are important to successful livestock production. Unfortunately use of antibiotics applies selection pressure that results in antibiotic resistance in exposed populations of bacteria and can also result in antibiotic residues in meat and milk from treated animals. Of major current concern is the risk of transfer of antibiotic resistant bacteria and genes encoding resistance from peo...
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Serious infections caused by bacteria that have become resistant to commonly used antibiotics have become a major global healthcare problem in the 21st century. They not only are more severe and require longer and more complex treatments, but they are also significantly more expensive to diagnose and to treat. Antibiotic resistance, initially a problem of the hospital setting associated with an...
متن کاملPdtaS Deficiency Affects Resistance of Mycobacteria to Ribosome Targeting Antibiotics
Two-component regulatory systems (TCSSs) are key regulatory elements responsible for the adaptation of bacteria to environmental stresses. A classical TCSS is typically comprised of a sensory histidine kinase and a corresponding response regulator. Here, we used homologous recombination to construct a Mycobacterium smegmatis mutant defective in the synthesis of cytosolic histidine kinase PdtaS ...
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ژورنال
عنوان ژورنال: ACS Pharmacology & Translational Science
سال: 2020
ISSN: 2575-9108,2575-9108
DOI: 10.1021/acsptsci.0c00053